
IMAGE SOURCE, REUTERS Image caption, Antony Blinken (file image) said the US was working “overtime” to solve the mystery
Three diplomats became sick in the Swiss city and one in the French capital last summer, with some 200 people affected over five years.
Secretary of State Antony Blinken said the American government was working to get to the bottom of the mystery.
There are fears an adversary may have targeted diplomats with microwaves.
Mr Blinken said the issue had been raised with Russia but no determination had been made.
Havana syndrome first emerged in Cuba in 2016 and has affected US diplomats, spies, officials and family members, as well as a number of Canadian diplomatic staff deployed in Cuba.
The latest cases include one person who was evacuated from Switzerland to the US for treatment, media reports say.
Mr Blinken told MSNBC in an interview that he had met state department employees around the world who had described their illnesses and how their lives had been disrupted.
People, he said, had been “directly and powerfully affected”.
“To date, we don’t know exactly what’s happened and we don’t know exactly who is responsible,” he told the broadcaster.
“We are working overtime across the entire government to get to the bottom of what happened, who’s responsible,” he said.
A more innocent, but also unproven, theory is that those who got sick suffered from a mass condition brought on by some stressful underlying situation.